Fexofenadine 120mg

Empress F

Technically Empress F is a Blend of Solublisers which supports solubility of Fexofenadine with lactose base, It has good effect on the tablets formulation where we have issues with its Dissolution

FormulationClaim per tabFunction
Ingredient
Mixing:
Fexofenadine120 mgActive Pharmaceutical Ingradient
Empress F120mgSolubliser
Tween 805 mgsurfactant
Empress U5 mgsolubliser
Binding
IPAQSVehicle
Lubrication
Lactose50 mg
Mg. Stearate3.0 mgLubricant
Talc3.0 mgLubricant
Aerosil1 mgGlident
Cross Povidone9 mgSuper Disintigerent
Empress U5 mgSolubliser

Physical properties of tablets

Avg. Weight-320 mg
Hardness-7-8kg/cm2

Procedure

  • Part I
    • Slurry preparation:
      1. Dissolve Empress F and tween 80 in about as much ipa to make a free flowing slurry, now slowly add Fexofenadine and stir it continuous to prepare slurry and keep it aside for 4 hours ( minimum time recommended)
    • Binding and sizing:
      1. Now add Lactose in it by passing through #40 mesh sieve
      2. Dry the lump in fbd or tray dryer with inlet temp of 400C till lod reaches 2% or less
      3. Size the granules with #30 mesh and break the retention with 1mm perforated screen in multimill
    • Lubrication:
      1. Sift Talc, Magnesium Stearate, and Cross Povidone from #60 sieve and Aerosil from #40 mesh
      2. Mix above mixture with sized granules of step 6 in suitable blender.
      3. Compress the tablet having hardness 7-8 kg/cm2.

Note :

  1. This is the tentative formulation and the information is based on laboratory work with small scale equipment and does not indicate the product performance.
  2. Full scale testing and end product performance are the responsibility of the user.
  3. We suggest that you may be increase or decrease the quantity of polymer and types of Excipients according to your final formulation/requirements.